Ehlers-Danlos syndrome, resulting from mutations in genes coding for particular types of collagens, leads to extremely loose joints and elasticity of the skin, in addition to problems with the intestines and arteries. (different to those types causing osteogenesis imperfecta).
Nicolo Paganini of Genoa, proclaimed by many as the greatest violinist who ever lived, was said have suffered, his hyperextensible joints allowing him extraordinary flexibility and dexterity in his fingers. However, the disease also led to him suffering numerous recurrent bouts of severe abdominal pain
Many people with this syndrome show extreme skin elasticity. For instance Garry "Stretch" Turner, as a result of his stretchy skin, currently holds the record for having the most clothes pegs attached to his face – 153!